Benign and hyperplastic endometrial changes associated with tamoxifen use.
نویسنده
چکیده
For nearly 20 years, tamoxifen has been successfully used in the management of breast cancer. Tamoxifen is a mixed estrogen agonist/antagonist that has a proliferative effect on the endometrium. The drug has been associated with a higher percentage of endometrial polyps and hyperplasia than in control patients as well as slightly increased risk of endometrial cancer. Although patients need to undergo annual gynecologic exams and abnormal vaginal bleeding needs to be aggressively followed up, the utility of routine gynecologic screening of tamoxifen patients has not been established and requires further study. Transvaginal sonography is a useful tool for detecting endometrial proliferation; however, an appropriate cut-off point for further intervention must be established. A cut-off point that is too low for abnormal endometrial thickness would result in a large number of unnecessary endometrial biopsies. Routine office endometrial biopsy needs further study as a screening method for breast cancer patients on tamoxifen.
منابع مشابه
Giant Endometrial Polyp in a Postmenopausal Woman without any complaints: A Case Report
Endometrial polyps are one of the most common etiologies of abnormal genital bleeding in both premenopausal and postmenopausal women. They are hyperplastic overgrowths of endometrial glands and stroma that form a projection from the surface of the endometrium. They may also be asymptomatic. The great majority of endometrial polyps are benign, but malignancy occurs in some women. Single or multi...
متن کاملPrevalence of endometrial proliferation in pipelle biopsies in tamoxifen-treated postmenopausal women with breast cancer in Kuwait.
OBJECTIVE To determine the prevalence of pathologic changes in the endometrium of tamoxifen-treated asymptomatic postmenopausal patients with breast cancer. SUBJECTS AND METHODS Fifty postmenopausal asymptomatic breast cancer patients with positive estrogen receptor status were treated with 20 mg of tamoxifen daily for a period of 5-60 months. The control group consisted of 30 asymptomatic po...
متن کاملPathology of endometrium treated with tamoxifen.
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متن کاملTamoxifen-associated polypoid endometriosis mimicking an ovarian neoplasm
Tamoxifen has been widely used for adjuvant treatment of breast cancer, but several gynecological side effects have been noted, including endometrial hyperplasia, polyp and carcinoma. Polypoid endometriosis is one of the extremely rare benign complications associated with tamoxifen therapy. A 66-year-old postmenopausal woman, who had received left partial mastectomy due to breast cancer (about ...
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ورودعنوان ژورنال:
- Oncology
دوره 11 2 Suppl 1 شماره
صفحات -
تاریخ انتشار 1997